ARHGAP45

Across TCGA pan-cancer cohorts, ARHGAP45 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ARHGAP45 data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ARHGAP45 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ARHGAP45 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and ACC are the cancer types where ARHGAP45 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.756	0.635	<.001	120	view →
UCEC	DFS	Median	All	0.740	0.538	<.001	80	view →
ACC	OS	Tertile	All	0.751	0.974	<.001	75	view →
LUAD	OS	Median	All	0.752	0.627	<.001	68	view →
UVM	DFS	Tertile	II,III,IV	0.621	0.916	.006	52	view →
LGG	DFS	Median	All	0.317	0.471	<.001	51	view →
SKCM	OS	Quartile	II,III,IV	0.556	0.301	.003	36	view →
MESO	OS	Median	II,III,IV	0.299	0.499	.006	31	view →
COAD	OS	Tertile	IV	0.276	0.673	.002	31	view →
LAML	DFS	Quartile	All	0.320	0.689	.007	28	view →
THYM	OS	Tertile	All	1.000	0.677	.001	20	view →
ESCA	DFS	Quartile	II,III,IV	0.531	0.220	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ARHGAP45–HNSC (DFS)

Open the HNSC breakdown →