ARHGAP45

Across TCGA patient cohorts, ARHGAP45 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ARHGAP45-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and Rictor. Each is linked with ARHGAP45 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP45-to-partner and partner-to-ARHGAP45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARHGAP45-low versus ARHGAP45-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP45→partner) and Y-score (partner→ARHGAP45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.418	+2.824	<.001	.034	3	3
COAD	INPP4B →	-0.624	-3.169	<.001	.017	3	2
COAD	Rictor →	-1.313	-3.450	.003	.005	3	2
COAD	Tuberin_pT1462 →	-0.182	-3.169	.015	.018	3	2
COAD	c-Kit →	-0.889	-2.313	.001	.035	3	2
COAD	4E-BP1 →	+0.389	+2.330	<.001	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by ARHGAP45 expression — COAD

Explore this box plot interactively →