ARHGAP45

Across TCGA cell cohorts, ARHGAP45 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,845 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGAP45-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of anaphase-promoting complex-dependent catabolic process, and Negative regulation of autophagosome maturation. Each is linked with ARHGAP45 in more than 10 cancer types. Because this analysis shows association rather than direction, both ARHGAP45-to-partner and partner-to-ARHGAP45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by ARHGAP45-low versus ARHGAP45-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP45→partner) and Y-score (partner→ARHGAP45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.099	+1.242	.001	<.001	3	11
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.128	+1.162	.001	<.001	3	10
SOFT_TISSUE	Negative regulation of autophagosome maturation →	+0.084	+1.568	<.001	<.001	3	10
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.115	+1.199	<.001	<.001	3	10
URINARY_TRACT	Viral genome replication →	+0.146	+0.855	<.001	<.001	3	10
URINARY_TRACT	Secondary metabolic process →	-0.224	-0.900	.001	.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,845 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by ARHGAP45 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →