ARHGAP45

Across TCGA cell cohorts, ARHGAP45 mutation is significantly associated with the RNA expression of many other genes, with 580 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP45-associated genes across cancer lineages are CBY1, HMGXB4, and TRMU. Each is linked with ARHGAP45 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP45-to-partner and partner-to-ARHGAP45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by ARHGAP45-low versus ARHGAP45-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP45→partner) and Y-score (partner→ARHGAP45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.662	+3.482	<.001	<.001	3	2
LARGE_INTESTINE	HMGXB4 →	+0.527	+2.628	.003	.002	3	2
LARGE_INTESTINE	TRMU →	+0.564	+2.628	.001	.002	3	2
LARGE_INTESTINE	RAD51C →	+0.870	+2.714	.001	.002	3	2
LARGE_INTESTINE	UFSP2 →	+0.545	+3.252	<.001	.002	3	2
LARGE_INTESTINE	C12orf57 →	+0.737	+3.082	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 580 associations by consensus.

CBY1 by ARHGAP45 expression — LARGE_INTESTINE

Explore this box plot interactively →