ARHGAP29

Across TCGA patient cohorts, ARHGAP29 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP29-associated genes across cancer lineages are Cyclin-B1, RBM15, and NF2. Each is linked with ARHGAP29 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP29-to-partner and partner-to-ARHGAP29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ARHGAP29-low versus ARHGAP29-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP29→partner) and Y-score (partner→ARHGAP29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.835	+2.700	<.001	<.001	3	3
UCEC	RBM15 →	+0.297	+2.502	.004	.001	3	3
LUSC	NF2 →	+0.281	+2.816	.018	.036	3	2
UCEC	C-Raf →	+0.169	+2.662	<.001	<.001	3	2
SKCM	EGFR →	-0.175	-2.807	.001	.003	3	2
UCEC	ACC_pS79 →	+0.237	+1.495	.035	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Cyclin-B1 by ARHGAP29 expression — UCEC

Explore this box plot interactively →