ARHGAP27

Across TCGA pan-cancer cohorts, ARHGAP27 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ARHGAP27 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ARHGAP27 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ARHGAP27 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where ARHGAP27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.386	.002	52	view →
HNSC	OS	Tertile	All	0.832	0.582	.008	20	view →
LUAD	OS	Median	II,III,IV	0.336	1.000	<.001	8	view →
LSCC	DFS	Median	II,III,IV	0.838	0.688	.033	4	view →
CCRCC	DFS	Quartile	All	0.953	0.423	.014	3	view →
PDAC	DFS	Median	III,IV	0.333	0.696	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ARHGAP27–UCEC (DFS)

Open the UCEC breakdown →