ARHGAP27

Across TCGA pan-cancer cohorts, ARHGAP27 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARHGAP27’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ARHGAP27 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARHGAP27 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRP, KIRC, and THCA are the cancer types where ARHGAP27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGAP27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.380	<.001	11	view →
KIRC	Female	All	+0.960	<.001	11	view →
THCA	Male	All	+0.607	<.001	6	view →
CHOL	Female	All	+2.566	<.001	5	view →
BLCA	Male	III,IV	+1.581	.030	5	view →
STAD	All	All	+0.975	.004	4	view →
LIHC	Female	All	+0.967	<.001	4	view →
BRCA	All	IV	−0.689	.029	2	view →
UCEC	All	All	+0.508	.037	2	view →
KICH	Male	All	−0.418	.025	2	view →
LUSC	Male	III,IV	+0.737	.038	1	view →
LUSC	Female	All	−0.424	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

ARHGAP27–KIRP

Open the KIRP breakdown →