ARHGAP27

Across TCGA patient cohorts, ARHGAP27 mutation is significantly associated with the RNA expression of many other genes, with 2,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP27-associated genes across cancer lineages are EME1, SASS6, and TYW3. Each is linked with ARHGAP27 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP27-to-partner and partner-to-ARHGAP27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by ARHGAP27-low versus ARHGAP27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP27→partner) and Y-score (partner→ARHGAP27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.502	+2.949	.001	<.001	3	3
UCEC	SASS6 →	+0.464	+2.321	.003	<.001	3	3
UCEC	TYW3 →	+0.347	+3.502	.005	.002	3	3
UCEC	PIGA →	+0.415	+2.600	.003	<.001	3	3
UCEC	POLQ →	+0.415	+1.888	.007	.004	3	3
UCEC	SPAG5 →	+0.511	+2.000	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,084 associations by consensus.

EME1 by ARHGAP27 expression — UCEC

Explore this box plot interactively →