ARHGAP27

Across TCGA patient cohorts, ARHGAP27 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP27-associated genes across cancer lineages are Caspase-7-cleavedD198, Annexin-1, and 14-3-3_beta. Each is linked with ARHGAP27 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARHGAP27-to-partner and partner-to-ARHGAP27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARHGAP27-low versus ARHGAP27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP27→partner) and Y-score (partner→ARHGAP27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.664	+2.926	.001	<.001	3	5
UCEC	Annexin-1 →	+0.504	+2.584	.007	.010	3	2
UCEC	14-3-3_beta →	-0.104	-2.558	.004	.010	3	1
UCEC	eIF4E →	+0.224	+1.925	.003	.005	3	1
UCEC	A-Raf_pS299 →	-0.139	-1.807	.001	.025	3	1
UCEC	ERK2 →	+0.139	+3.321	.044	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Caspase-7-cleavedD198 by ARHGAP27 expression — UCEC

Explore this box plot interactively →