ARHGAP27

Across TCGA cell cohorts, ARHGAP27 mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP27-associated genes across cancer lineages are MSTN, PRR23C, and AWAT1. Each is linked with ARHGAP27 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP27-to-partner and partner-to-ARHGAP27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSTN grouped by ARHGAP27-low versus ARHGAP27-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP27→partner) and Y-score (partner→ARHGAP27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSTN →	+0.155	+3.537	.006	.001	3	2
LUNG_NSCLC_LUAD	PRR23C →	+0.006	+5.228	.005	.005	3	2
LUNG_NSCLC_LUSC	AWAT1 →	+0.036	+4.108	<.001	.005	3	1
OVARY	KRTAP19-8 →	+0.410	+5.807	<.001	.001	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
CNS	TAS2R7 →	+0.035	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

MSTN by ARHGAP27 expression — LARGE_INTESTINE

Explore this box plot interactively →