ARHGAP26

Across TCGA patient cohorts, ARHGAP26 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP26-associated genes across cancer lineages are JNK2, Cyclin-B1, and eIF4G. Each is linked with ARHGAP26 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP26-to-partner and partner-to-ARHGAP26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ARHGAP26-low versus ARHGAP26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP26→partner) and Y-score (partner→ARHGAP26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.225	+1.916	<.001	.009	3	2
UCEC	Cyclin-B1 →	+0.668	+2.432	<.001	<.001	3	2
UCEC	eIF4G →	+0.299	+2.807	.002	.002	3	1
UCEC	A-Raf_pS299 →	-0.151	-3.247	<.001	<.001	3	1
UCEC	ERK2 →	+0.221	+2.115	<.001	<.001	3	1
UCEC	FoxM1 →	+0.208	+1.584	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

JNK2 by ARHGAP26 expression — UCEC

Explore this box plot interactively →