ARHGAP26

Across TCGA pan-cancer cohorts, ARHGAP26 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARHGAP26’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARHGAP26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARHGAP26 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where ARHGAP26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGAP26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.179	<.001	11	view →
KICH	Female	All	−1.314	<.001	8	view →
KIRP	All	All	+0.745	<.001	8	view →
THCA	All	II,III,IV	−0.533	<.001	8	view →
LIHC	All	II,III,IV	+0.753	<.001	7	view →
BRCA	All	All	−0.879	<.001	6	view →
STAD	Male	II,III,IV	+0.852	<.001	6	view →
ESCA	All	All	+1.308	.008	4	view →
LUAD	All	All	+0.459	.002	4	view →
LUSC	All	All	−0.432	<.001	3	view →
CHOL	All	All	+1.503	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ARHGAP26–KIRC

Open the KIRC breakdown →