ARHGAP26

Across TCGA cell cohorts, ARHGAP26 mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP26-associated genes across cancer lineages are JOSD1, POLDIP3, and TNFRSF10A. Each is linked with ARHGAP26 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP26-to-partner and partner-to-ARHGAP26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by ARHGAP26-low versus ARHGAP26-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP26→partner) and Y-score (partner→ARHGAP26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JOSD1 →	+0.612	+3.364	.001	.002	3	1
LARGE_INTESTINE	POLDIP3 →	+0.584	+3.364	.003	.002	3	1
LARGE_INTESTINE	TNFRSF10A →	+0.956	+3.451	.001	.002	3	1
LARGE_INTESTINE	SLAIN2 →	+0.697	+3.364	.001	.002	3	1
LARGE_INTESTINE	VPS4B →	+0.723	+3.364	.002	.002	3	1
LARGE_INTESTINE	SMU1 →	+0.449	+3.451	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

JOSD1 by ARHGAP26 expression — LARGE_INTESTINE

Explore this box plot interactively →