ARHGAP25

Across TCGA patient cohorts, ARHGAP25 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP25-associated genes across cancer lineages are ATM, Acetyl-a-Tubulin-Lys40, and Annexin-1. Each is linked with ARHGAP25 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP25-to-partner and partner-to-ARHGAP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ARHGAP25-low versus ARHGAP25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP25→partner) and Y-score (partner→ARHGAP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.434	-1.415	.002	.010	3	3
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.415	+1.440	.029	.023	3	2
UCEC	Annexin-1 →	+0.536	+2.107	.001	.002	3	2
SKCM	cIAP →	+0.136	+2.115	.007	.015	3	2
UCEC	Cyclin-B1 →	+0.710	+2.169	<.001	<.001	3	2
COAD	eIF4E →	+0.207	+2.820	.018	.035	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ATM by ARHGAP25 expression — UCEC

Explore this box plot interactively →