ARHGAP25

Across TCGA pan-cancer cohorts, ARHGAP25 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ARHGAP25 data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ARHGAP25 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ARHGAP25 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, UVM, and HNSC are the cancer types where ARHGAP25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.410	0.256	<.001	108	view →
UVM	DFS	Median	All	0.425	0.725	<.001	94	view →
HNSC	DFS	Tertile	All	0.698	0.510	<.001	76	view →
LUAD	DFS	Median	All	0.741	0.593	<.001	60	view →
LGG	OS	Median	All	0.354	0.570	<.001	54	view →
CESC	DFS	Tertile	II,III,IV	0.926	0.651	<.001	48	view →
KIRC	DFS	Tertile	III,IV	0.520	0.324	.006	45	view →
BRCA	DFS	Quartile	All	0.541	0.463	.003	28	view →
SCLC	DFS	Tertile	II,III,IV	0.706	0.357	.001	26	view →
UCEC	OS	Tertile	III,IV	0.681	0.398	.017	24	view →
KIRP	DFS	Median	All	0.612	0.885	.004	23	view →
SARC	OS	Quartile	All	0.848	0.665	.002	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ARHGAP25–SKCM (OS)

Open the SKCM breakdown →