ARHGAP25

Across TCGA cell cohorts, ARHGAP25 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP25-associated genes across cancer lineages are DBX2, DEFB118, and CBLIF. Each is linked with ARHGAP25 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP25-to-partner and partner-to-ARHGAP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX2 grouped by ARHGAP25-low versus ARHGAP25-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP25→partner) and Y-score (partner→ARHGAP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DBX2 →	+0.008	+2.977	<.001	.006	3	2
LUNG_NSCLC_LUAD	DEFB118 →	+0.008	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	CBLIF →	+0.019	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	OPRPN →	+0.042	+4.472	<.001	.001	3	1
LARGE_INTESTINE	LUZP4 →	+0.011	+2.669	<.001	.004	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

DBX2 by ARHGAP25 expression — LARGE_INTESTINE

Explore this box plot interactively →