ARHGAP24

Across TCGA patient cohorts, ARHGAP24 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP24-associated genes across cancer lineages are ACVRL1, p38-MAPK_pT180_Y182, and TFRC. Each is linked with ARHGAP24 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP24-to-partner and partner-to-ARHGAP24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by ARHGAP24-low versus ARHGAP24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP24→partner) and Y-score (partner→ARHGAP24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.108	-2.102	.010	.016	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.365	-1.401	.008	.010	3	2
UCEC	TFRC →	+0.393	+3.321	.017	.009	3	2
UCEC	ASNS →	+0.269	+1.502	.016	.027	3	2
UCEC	ATM →	-0.790	-2.485	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.539	+2.267	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ACVRL1 by ARHGAP24 expression — UCEC

Explore this box plot interactively →