ARHGAP24

Across TCGA pan-cancer cohorts, ARHGAP24 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ARHGAP24’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARHGAP24 RNA is repressed in tumor relative to normal tissue. In most cancer types ARHGAP24 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where ARHGAP24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARHGAP24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.466	<.001	12	view →
THCA	Male	III,IV	−3.027	<.001	11	view →
KICH	Male	III,IV	−2.474	<.001	11	view →
LUAD	All	III,IV	−1.609	<.001	11	view →
KIRP	Male	III,IV	−1.384	<.001	11	view →
BLCA	Male	All	−1.587	.001	8	view →
LUSC	Male	II,III,IV	−1.448	<.001	7	view →
UCEC	All	All	−1.436	<.001	6	view →
BRCA	All	All	−0.922	<.001	6	view →
STAD	All	All	−0.560	.002	6	view →
COAD	Female	All	−0.418	.012	3	view →
READ	Female	All	−1.168	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ARHGAP24–KIRC

Open the KIRC breakdown →