ARHGAP23

Across TCGA cell cohorts, ARHGAP23 mutation is significantly associated with the RNA expression of many other genes, with 1,012 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP23-associated genes across cancer lineages are PAPOLB, SGCB, and UBTD2. Each is linked with ARHGAP23 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP23-to-partner and partner-to-ARHGAP23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAPOLB grouped by ARHGAP23-low versus ARHGAP23-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP23→partner) and Y-score (partner→ARHGAP23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PAPOLB →	+0.031	+3.836	<.001	.004	3	2
BLOOD_Leukemia	SGCB →	+1.111	+2.614	.003	.003	3	2
BLOOD_Leukemia	UBTD2 →	+0.938	+2.674	.006	.003	3	2
LARGE_INTESTINE	ACTR6 →	+0.715	+2.584	<.001	.002	3	2
LARGE_INTESTINE	RSPH4A →	+0.183	+2.244	.002	.003	3	2
LARGE_INTESTINE	ACADM →	+0.676	+2.158	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,012 associations by consensus.

PAPOLB by ARHGAP23 expression — OESOPHAGUS

Explore this box plot interactively →