ARHGAP21

Across TCGA patient cohorts, ARHGAP21 mutation is significantly associated with the RNA expression of many other genes, with 7,071 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP21-associated genes across cancer lineages are MIR26A1, ZFP64P1, and PTS. Each is linked with ARHGAP21 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP21-to-partner and partner-to-ARHGAP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR26A1 grouped by ARHGAP21-low versus ARHGAP21-high in ACC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP21→partner) and Y-score (partner→ARHGAP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	MIR26A1 →	+0.424	+5.228	<.001	.005	3	3
ACC	ZFP64P1 →	+0.072	+5.228	<.001	.005	3	3
UCEC	PTS →	+0.242	+1.914	.002	<.001	3	3
UCEC	EME1 →	+0.493	+1.595	<.001	<.001	3	3
UCEC	TSPAN7 →	-0.779	-1.126	<.001	.002	3	3
UCEC	SUSD3 →	-0.500	-2.137	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,071 associations by consensus.

MIR26A1 by ARHGAP21 expression — ACC

Explore this box plot interactively →