ARHGAP21

Across TCGA pan-cancer cohorts, ARHGAP21 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ARHGAP21 data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ARHGAP21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARHGAP21 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

BLCA, KIRC, and SKCM are the cancer types where ARHGAP21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	All	0.171	0.682	<.001	79	view →
KIRC	DFS	Median	All	0.767	0.494	<.001	78	view →
SKCM	DFS	Quartile	II,III,IV	0.373	0.144	<.001	77	view →
LUAD	DFS	Tertile	All	0.197	0.476	<.001	42	view →
PAAD	DFS	Median	All	0.176	0.396	.002	38	view →
LIHC	OS	Median	All	0.721	0.831	.001	33	view →
ESCA	OS	Median	III,IV	0.561	0.313	.009	24	view →
CESC	DFS	Quartile	All	0.689	0.874	.008	22	view →
DLBC	DFS	Median	All	0.619	0.919	.008	20	view →
KICH	DFS	Quartile	II,III,IV	0.360	0.930	.004	18	view →
ACC	OS	Tertile	IV	1.000	0.658	.013	14	view →
OV	DFS	Median	III,IV	0.495	0.566	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ARHGAP21–BLCA (DFS)

Open the BLCA breakdown →