ARHGAP21

Across TCGA patient cohorts, ARHGAP21 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP21-associated genes across cancer lineages are GAPDH, INPP4B, and TFRC. Each is linked with ARHGAP21 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARHGAP21-to-partner and partner-to-ARHGAP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ARHGAP21-low versus ARHGAP21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP21→partner) and Y-score (partner→ARHGAP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.366	+1.736	.006	.005	3	4
COAD	INPP4B →	-0.470	-3.584	.001	.002	3	3
SKCM	TFRC →	+0.456	+1.874	.041	.049	3	3
UCEC	eEF2 →	+0.272	+2.070	.002	.001	3	3
UCEC	Cyclin-B1 →	+0.475	+2.263	<.001	<.001	3	3
LUAD	FOXO3a →	-0.140	-3.000	.021	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

GAPDH by ARHGAP21 expression — UCEC

Explore this box plot interactively →