ARHGAP21

Across TCGA cell cohorts, ARHGAP21 mutation is significantly associated with the RNA expression of many other genes, with 538 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARHGAP21-associated genes across cancer lineages are OR11H6, KSR2, and TNK1. Each is linked with ARHGAP21 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP21-to-partner and partner-to-ARHGAP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H6 grouped by ARHGAP21-low versus ARHGAP21-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP21→partner) and Y-score (partner→ARHGAP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR11H6 →	+0.016	+4.321	.001	.009	3	3
BLOOD_Leukemia	KSR2 →	+0.304	+2.698	<.001	.002	3	2
BLOOD_Leukemia	TNK1 →	+1.023	+3.351	<.001	.003	3	2
BLOOD_Leukemia	BLOC1S2 →	+0.505	+3.470	.002	.002	3	2
LARGE_INTESTINE	MTMR4 →	+0.685	+3.364	.004	.002	3	2
LARGE_INTESTINE	IRGC →	+0.055	+2.772	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 538 associations by consensus.

OR11H6 by ARHGAP21 expression — CNS

Explore this box plot interactively →