ARHGAP18

Across TCGA patient cohorts, ARHGAP18 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP18-associated genes across cancer lineages are Rad50, TFRC, and Caspase-7-cleavedD198. Each is linked with ARHGAP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP18-to-partner and partner-to-ARHGAP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ARHGAP18-low versus ARHGAP18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP18→partner) and Y-score (partner→ARHGAP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.227	-2.247	.010	.001	3	2
UCEC	TFRC →	+0.569	+2.321	.003	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.663	+2.242	.002	.005	3	2
UCEC	14-3-3_beta →	-0.090	-1.673	.014	.040	3	1
UCEC	EGFR_pY1068 →	-0.221	-2.115	.016	.017	3	1
UCEC	eIF4E →	+0.197	+2.736	.011	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Rad50 by ARHGAP18 expression — UCEC

Explore this box plot interactively →