ARHGAP18

Across TCGA cell cohorts, ARHGAP18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,214 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARHGAP18-associated GO terms across cancer lineages are Regulation of actin filament depolymerization, Death-inducing signaling complex assembly, and Epithelial cell fate commitment. Each is linked with ARHGAP18 in more than 9 cancer types. Because this analysis shows association rather than direction, both ARHGAP18-to-partner and partner-to-ARHGAP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of actin filament depolymerization grouped by ARHGAP18-low versus ARHGAP18-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP18→partner) and Y-score (partner→ARHGAP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of actin filament depolymerization →	+0.150	+1.603	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Death-inducing signaling complex assembly →	+0.180	+1.812	.001	.004	3	10
LUNG_NSCLC_LUSC	Epithelial cell fate commitment →	+0.192	+1.554	.002	.002	3	10
BLOOD_Leukemia	Muscle atrophy →	+0.489	+1.246	.001	<.001	3	10
BLOOD_Leukemia	Skeletal myofibril assembly →	+0.474	+0.994	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of actin filament organization →	+0.055	+1.475	.005	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,214 associations by consensus.

Regulation of actin filament depolymerization by ARHGAP18 expression — PANCREAS

Explore this box plot interactively →