Across TCGA patient cohorts, ARHGAP11A mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARHGAP11A-associated genes across cancer lineages are HSP70, LKB1, and NF2. Each is linked with ARHGAP11A in more than 2 cancer types. Because this analysis shows association rather than direction, both ARHGAP11A-to-partner and partner-to-ARHGAP11A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP11A→partner) and Y-score (partner→ARHGAP11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HSP70 →	-0.571	-2.987	.037	.035	3	3
UCEC	LKB1 →	-0.088	-2.000	.018	.030	3	3
UCEC	NF2 →	+0.217	+1.874	.004	.049	3	3
UCEC	FoxM1 →	+0.229	+2.232	.012	.005	3	2
UCEC	JNK2 →	+0.363	+2.392	<.001	<.001	3	2
UCEC	Notch1 →	+0.158	+2.128	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Exploration

ARHGAP11A survival (RNA) · tumor vs normal (RNA) · all ARHGAP11A data types