Across TCGA cell cohorts, ARHGAP11A mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ARHGAP11A-associated genes across cancer lineages are SMIM36, SLC22A8, and LACTBL1. Each is linked with ARHGAP11A in more than 1 cancer types. Because this analysis shows association rather than direction, both ARHGAP11A-to-partner and partner-to-ARHGAP11A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARHGAP11A→partner) and Y-score (partner→ARHGAP11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SMIM36 →	+0.040	+4.228	<.001	.006	3	2
CNS	SLC22A8 →	+0.904	+3.459	<.001	.006	3	2
CNS	LACTBL1 →	+0.362	+3.459	<.001	.006	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
OVARY	RGSL1 →	+0.051	+4.228	<.001	.006	3	1
OVARY	PRR23C →	+0.006	+4.990	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Exploration

ARHGAP11A survival (RNA) · tumor vs normal (RNA) · all ARHGAP11A data types