ARGLU1

Across TCGA patient cohorts, ARGLU1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARGLU1-associated genes across cancer lineages are A-Raf_pS299, N-Ras, and p53. Each is linked with ARGLU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARGLU1-to-partner and partner-to-ARGLU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ARGLU1-low versus ARGLU1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARGLU1→partner) and Y-score (partner→ARGLU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.153	-3.584	<.001	.002	3	2
UCEC	N-Ras →	-0.131	-1.664	.004	.023	3	2
UCEC	p53 →	-0.302	-1.678	.041	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.678	+2.019	.002	.017	3	2
UCEC	14-3-3_beta →	-0.101	-3.295	.008	.009	3	1
UCEC	eEF2 →	+0.364	+1.678	.008	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

A-Raf_pS299 by ARGLU1 expression — UCEC

Explore this box plot interactively →