ARGLU1

Across TCGA pan-cancer cohorts, ARGLU1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ARGLU1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ARGLU1 RNA is repressed in tumor relative to normal tissue. In most cancer types ARGLU1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, COAD, and LIHC are the cancer types where ARGLU1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARGLU1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.864	<.001	10	view →
COAD	Male	II,III,IV	+0.895	<.001	10	view →
LIHC	All	All	+0.549	<.001	8	view →
LUAD	All	II,III,IV	−0.691	<.001	7	view →
BRCA	All	III,IV	−0.871	<.001	6	view →
UCEC	All	All	−0.737	<.001	6	view →
LUSC	All	All	−0.438	.006	4	view →
CHOL	All	All	+1.895	<.001	3	view →
READ	All	All	+0.684	.016	2	view →
STAD	All	II,III,IV	+0.552	.020	2	view →
ESCA	All	All	+0.663	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ARGLU1–KICH

Open the KICH breakdown →