ARGLU1

Across TCGA cell cohorts, ARGLU1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,027 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ARGLU1-associated GO terms across cancer lineages are Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, mRNA splice site recognition, and Ribosomal protein import into nucleus. Each is linked with ARGLU1 in more than 15 cancer types. Because this analysis shows association rather than direction, both ARGLU1-to-partner and partner-to-ARGLU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery grouped by ARGLU1-low versus ARGLU1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARGLU1→partner) and Y-score (partner→ARGLU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.107	+0.823	<.001	.001	3	16
LARGE_INTESTINE	mRNA splice site recognition →	+0.146	+1.643	<.001	<.001	3	16
STOMACH	Ribosomal protein import into nucleus →	+0.121	+1.404	<.001	<.001	3	16
BONE	Microtubule nucleation →	+0.147	+1.480	<.001	<.001	3	15
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.122	+1.812	<.001	<.001	3	15
BONE	Centriole replication →	+0.141	+1.512	.005	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,027 associations by consensus.

Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery by ARGLU1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →