ARFGEF1

Across TCGA patient cohorts, ARFGEF1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGEF1-associated genes across cancer lineages are Caspase-7-cleavedD198, NDRG1_pT346, and 4E-BP1. Each is linked with ARFGEF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARFGEF1-to-partner and partner-to-ARFGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ARFGEF1-low versus ARFGEF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF1→partner) and Y-score (partner→ARFGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.047	+2.824	.002	.034	3	5
BLCA	NDRG1_pT346 →	+0.958	+3.169	.002	.018	3	3
COAD	4E-BP1 →	+0.294	+2.467	.001	.011	3	3
UCEC	eIF4E →	+0.132	+1.237	.018	.004	3	3
UCEC	FASN →	+0.242	+1.093	.020	.012	3	3
UCEC	ASNS →	+0.314	+1.321	.001	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by ARFGEF1 expression — COAD

Explore this box plot interactively →