ARFGEF1

Across TCGA cell cohorts, ARFGEF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,039 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARFGEF1-associated GO terms across cancer lineages are Anterograde dendritic transport of messenger ribonucleoprotein complex, Negative regulation of protein localization to centrosome, and Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway. Each is linked with ARFGEF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both ARFGEF1-to-partner and partner-to-ARFGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Anterograde dendritic transport of messenger ribonucleoprotein complex grouped by ARFGEF1-low versus ARFGEF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF1→partner) and Y-score (partner→ARFGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Anterograde dendritic transport of messenger ribonucleoprotein complex →	+0.218	+0.852	.002	.003	3	13
STOMACH	Negative regulation of protein localization to centrosome →	+0.110	+1.046	.002	<.001	2	12
OESOPHAGUS	Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway →	+0.125	+0.796	<.001	<.001	3	11
URINARY_TRACT	Glycerophospholipid metabolic process →	+0.035	+0.895	.006	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Protein targeting to lysosome →	+0.086	+0.682	.001	<.001	3	9
BREAST	Vacuolar transport →	+0.055	+0.982	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,039 associations by consensus.

Anterograde dendritic transport of messenger ribonucleoprotein complex by ARFGEF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →