ARFGEF1

Across TCGA cell cohorts, ARFGEF1 mutation is significantly associated with the RNA expression of many other genes, with 837 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ARFGEF1-associated genes across cancer lineages are EIF3L, KRTAP4-11, and PES1. Each is linked with ARFGEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFGEF1-to-partner and partner-to-ARFGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF3L grouped by ARFGEF1-low versus ARFGEF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGEF1→partner) and Y-score (partner→ARFGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3L →	+0.551	+2.546	<.001	.001	3	2
STOMACH	KRTAP4-11 →	+0.015	+4.285	<.001	.007	3	1
LARGE_INTESTINE	PES1 →	+0.462	+2.331	.004	.001	3	1
LARGE_INTESTINE	GCAT →	+1.234	+3.459	<.001	.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.487	+2.244	<.001	.003	3	1
LARGE_INTESTINE	CCDC134 →	+0.725	+2.850	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 837 associations by consensus.

EIF3L by ARFGEF1 expression — LARGE_INTESTINE

Explore this box plot interactively →