ARFGAP2

Across TCGA patient cohorts, ARFGAP2 mutation is significantly associated with the RNA expression of many other genes, with 1,706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARFGAP2-associated genes across cancer lineages are HMGB1P32, RN7SL169P, and RN7SKP24. Each is linked with ARFGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ARFGAP2-to-partner and partner-to-ARFGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P32 grouped by ARFGAP2-low versus ARFGAP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARFGAP2→partner) and Y-score (partner→ARFGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HMGB1P32 →	+0.180	+5.588	<.001	<.001	3	2
SKCM	RN7SL169P →	+0.088	+5.382	<.001	<.001	3	2
CESC	RN7SKP24 →	+0.308	+5.144	<.001	.003	3	2
LUAD	IGHVIII-22-2 →	+0.809	+3.690	.008	.009	3	2
LUAD	CSGALNACT2P2 →	+0.148	+4.037	<.001	.004	3	2
LUAD	CYP3A52P →	+0.482	+4.093	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,706 associations by consensus.

HMGB1P32 by ARFGAP2 expression — COAD

Explore this box plot interactively →