ARF4-AS1

Across TCGA pan-cancer cohorts, ARF4-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ARF4-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ARF4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ARF4-AS1 expression acts as an unfavorable survival marker, although some lineages such as THYM and STAD show a favorable association.

KIRC, THYM, and STAD are the cancer types where ARF4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.755	0.854	<.001	137	view →
THYM	OS	Median	All	1.000	0.742	.001	36	view →
STAD	DFS	Quartile	IV	0.773	0.132	.003	34	view →
LUSC	DFS	Median	II,III,IV	0.633	0.775	.007	31	view →
BRCA	OS	Median	IV	0.856	0.360	.002	27	view →
CESC	DFS	Tertile	IV	0.279	0.803	.006	26	view →
LUAD	OS	Quartile	All	0.856	0.756	.007	20	view →
LIHC	DFS	Median	III,IV	0.110	0.288	.007	20	view →
PRAD	DFS	Median	All	0.705	0.873	.003	18	view →
COAD	DFS	Tertile	All	0.624	0.775	.006	12	view →
PCPG	OS	Median	All	1.000	0.734	.023	10	view →
SARC	DFS	Quartile	All	0.484	0.724	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ARF4-AS1–KIRC (OS)

Open the KIRC breakdown →