ARF4-AS1

Across TCGA pan-cancer cohorts, ARF4-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ARF4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ARF4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ARF4-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where ARF4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARF4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.806	<.001	9	view →
LIHC	Male	All	+0.621	<.001	8	view →
THCA	All	All	−0.224	.002	4	view →
BRCA	All	All	−0.146	.007	4	view →
COAD	All	All	+0.237	.010	2	view →
BLCA	Female	IV	+0.413	.044	1	view →
CHOL	All	All	+0.387	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ARF4-AS1–KICH

Open the KICH breakdown →