ARCN1

Across TCGA pan-cancer cohorts, ARCN1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ARCN1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ARCN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARCN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where ARCN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.540	0.849	.009	14	view →
UCEC	DFS	Tertile	All	0.968	0.742	.005	12	view →
CCRCC	DFS	Tertile	III,IV	0.550	0.867	.006	10	view →
PDAC	OS	Tertile	III,IV	0.858	0.387	.027	9	view →
HNSC	DFS	Quartile	All	1.000	0.304	.033	7	view →
LUAD	OS	Median	All	0.600	0.852	.048	2	view →
GBM	DFS	Quartile	All	0.698	0.876	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ARCN1–LSCC (DFS)

Open the LSCC breakdown →