ARCN1

Across TCGA pan-cancer cohorts, ARCN1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ARCN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ARCN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARCN1 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where ARCN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARCN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.790	<.001	11	view →
KIRC	Female	III,IV	+0.531	<.001	9	view →
LUAD	Male	II,III,IV	+0.882	<.001	8	view →
THCA	All	All	−0.270	.003	8	view →
STAD	All	II,III,IV	+0.548	.002	6	view →
BRCA	Female	All	+0.260	<.001	6	view →
LIHC	All	All	+0.410	<.001	5	view →
LUSC	Male	All	+0.353	<.001	5	view →
CHOL	All	All	+0.987	.001	2	view →
PRAD	All	All	+0.220	.028	2	view →
READ	Female	All	−0.282	.046	1	view →
COAD	Male	II,III,IV	+0.238	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ARCN1–HNSC

Open the HNSC breakdown →