Across TCGA patient cohorts, ARC RNA expression is significantly associated with the protein abundance of many other proteins, with 8,428 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ARC-associated proteins across cancer lineages are RNF213, ADGRL2, and MAPK12. Each is linked with ARC in more than 3 cancer types. Because this analysis shows association rather than direction, both ARC-to-partner and partner-to-ARC results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ARC→partner) and Y-score (partner→ARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNF213 →	-0.351	-0.532	<.001	<.001	3	4
GBM	ADGRL2 →	+0.460	+1.137	<.001	<.001	3	4
CCRCC	MAPK12 →	+0.587	+0.585	<.001	<.001	3	4
COAD	PROC →	+0.618	+0.630	.002	.008	3	3
HNSC	CARD11 →	-0.349	-0.422	<.001	.005	3	3
GBM	CD53 →	-0.410	-1.033	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,428 associations by consensus.

Exploration

ARC survival (RNA) · tumor vs normal (RNA) · all ARC data types