Across TCGA cell cohorts, ARC mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ARC-associated genes across cancer lineages are C20orf85, GSG1L2, and USP29. Each is linked with ARC in more than 1 cancer types. Because this analysis shows association rather than direction, both ARC-to-partner and partner-to-ARC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARC→partner) and Y-score (partner→ARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	2
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	2
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.017	+4.662	<.001	.005	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	CST5 →	+0.536	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

ARC survival (RNA) · tumor vs normal (RNA) · all ARC data types