ARAP3

Across TCGA patient cohorts, ARAP3 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARAP3-associated genes across cancer lineages are 4E-BP1, p62 Lck ligand, and Caspase-7-cleavedD198. Each is linked with ARAP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ARAP3-to-partner and partner-to-ARAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ARAP3-low versus ARAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAP3→partner) and Y-score (partner→ARAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.229	+1.999	.003	.008	3	4
LUSC	p62 Lck ligand →	+0.818	+2.816	.010	.036	3	3
COAD	Caspase-7-cleavedD198 →	+1.532	+2.593	<.001	.006	3	3
UCEC	STAT3_pY705 →	-0.265	-1.392	<.001	.015	3	3
UCEC	TFRC →	+0.469	+1.925	.002	.004	3	3
UCEC	ATM →	-0.470	-1.736	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

4E-BP1 by ARAP3 expression — UCEC

Explore this box plot interactively →