Across TCGA patient cohorts, ARAP1 mutation is significantly associated with the RNA expression of many other genes, with 5,259 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARAP1-associated genes across cancer lineages are RANBP1, PTTG1, and MELK. Each is linked with ARAP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ARAP1-to-partner and partner-to-ARAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAP1→partner) and Y-score (partner→ARAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RANBP1 →	+0.459	+2.208	<.001	<.001	3	5
SKCM	PTTG1 →	+0.443	+2.597	.005	.005	3	4
SKCM	MELK →	+0.677	+1.591	<.001	.006	3	4
UCEC	LSM3 →	+0.500	+1.857	<.001	<.001	3	4
SKCM	MRPS22 →	+0.394	+2.569	.001	<.001	3	4
UCEC	FAM136A →	+0.354	+2.098	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,259 associations by consensus.

Exploration

ARAP1 survival (RNA) · tumor vs normal (RNA) · all ARAP1 data types