Across TCGA pan-cancer cohorts, ARAP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ARAP1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ARAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ARAP1 is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.
KIRC, LIHC, and HNSC are the cancer types where ARAP1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ARAP1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.