ARAP1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ARAP1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ARAP1-associated genes across cancer lineages are PDCD4, PAI-1, and CDK1. Each is linked with ARAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ARAP1-to-partner and partner-to-ARAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAP1→partner) and Y-score (partner→ARAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPDCD4 →-0.415-2.000.007.02933
SKCMPAI-1 →+0.506+1.753.045.04723
SKCMCDK1 →+0.152+2.000.021.02932
SKCMCyclin-B1 →+0.494+1.887.001.02932
UCECKu80 →+0.198+1.405.010.01232
UCECMEK1 →+0.327+1.652.006.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

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