ARAP1-AS1

Across TCGA patient cohorts, ARAP1-AS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,665 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible ARAP1-AS1-associated GO terms across cancer lineages are Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, Positive regulation of DNA metabolic process, and Protein targeting to mitochondrion. Each is linked with ARAP1-AS1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ARAP1-AS1-to-partner and partner-to-ARAP1-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage grouped by ARAP1-AS1-low versus ARAP1-AS1-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAP1-AS1→partner) and Y-score (partner→ARAP1-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage →	+0.045	+0.138	<.001	<.001	3	15
KIRP	Positive regulation of DNA metabolic process →	+0.022	+0.128	<.001	<.001	3	13
KIRC	Protein targeting to mitochondrion →	+0.030	+0.162	<.001	<.001	3	13
UVM	Regulation of DNA-directed DNA polymerase activity →	+0.058	+0.043	<.001	.005	2	14
KIRC	Protein localization to mitochondrion →	+0.030	+0.159	<.001	<.001	3	12
LIHC	Positive regulation of nuclear cell cycle DNA replication →	+0.028	+0.182	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,665 associations by consensus.

Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by ARAP1-AS1 expression — KIRC

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