ARAF

Across TCGA patient cohorts, ARAF protein abundance is significantly associated with the RNA expression of many other genes, with 16,163 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ARAF-associated genes across cancer lineages are MAP4K4, RTKN, and TTL. Each is linked with ARAF in more than 4 cancer types. Because this analysis shows association rather than direction, both ARAF-to-partner and partner-to-ARAF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ARAF versus MAP4K4 in LSCC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAF→partner) and Y-score (partner→ARAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP4K4 →	-0.534	-0.184	<.001	<.001	3	5
LSCC	RTKN →	-0.634	-0.172	.001	<.001	3	4
LSCC	TTL →	-0.386	-0.133	.007	.005	3	4
LSCC	PTCD3 →	-0.375	-0.139	.001	<.001	3	4
LSCC	KIF13A →	-0.456	-0.086	<.001	.008	3	4
GBM	ZGRF1 →	-0.574	-0.315	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,163 associations by consensus.

ARAF vs MAP4K4 — LSCC

Explore this scatter interactively →