ARAF

Across TCGA pan-cancer cohorts, ARAF RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ARAF data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ARAF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ARAF expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

LGG, KIRC, and SCLC are the cancer types where ARAF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.671	0.806	<.001	48	view →
KIRC	DFS	Tertile	All	0.746	0.535	<.001	44	view →
SCLC	OS	Tertile	All	0.582	0.190	<.001	40	view →
SKCM	DFS	Median	All	0.658	0.564	.008	23	view →
UVM	DFS	Tertile	All	0.480	0.811	.017	23	view →
LUSC	OS	Median	IV	0.255	0.851	.021	17	view →
READ	DFS	Tertile	All	0.379	0.791	.014	16	view →
PAAD	DFS	Quartile	All	0.555	0.138	.005	14	view →
DLBC	DFS	Median	IV	1.000	0.223	.001	14	view →
ESCA	DFS	Tertile	IV	0.221	0.692	.024	12	view →
LUAD	DFS	Tertile	III,IV	0.374	0.683	.023	12	view →
UCEC	DFS	Median	IV	0.837	0.549	.032	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ARAF–LGG (DFS)

Open the LGG breakdown →