ARAF

Across TCGA patient cohorts, ARAF mutation is significantly associated with the RNA expression of many other genes, with 4,581 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARAF-associated genes across cancer lineages are LRRC59, PIP4K2C, and CIRBP-AS1. Each is linked with ARAF in more than 2 cancer types. Because this analysis shows association rather than direction, both ARAF-to-partner and partner-to-ARAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC59 grouped by ARAF-low versus ARAF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAF→partner) and Y-score (partner→ARAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LRRC59 →	+0.613	+2.496	<.001	<.001	3	3
UCEC	PIP4K2C →	+0.602	+2.169	<.001	<.001	3	3
UCEC	CIRBP-AS1 →	+0.383	+2.446	.002	.001	3	2
UCEC	CCL4 →	+0.681	+1.665	.001	.002	3	2
UCEC	CCL18 →	+1.170	+1.643	<.001	.003	3	2
UCEC	IL2RB →	+0.710	+2.180	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,581 associations by consensus.

LRRC59 by ARAF expression — UCEC

Explore this box plot interactively →