ARAF

Across TCGA patient cohorts, ARAF mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ARAF-associated genes across cancer lineages are ATM, EGFR_pY1068, and INPP4B. Each is linked with ARAF in more than 2 cancer types. Because this analysis shows association rather than direction, both ARAF-to-partner and partner-to-ARAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ARAF-low versus ARAF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAF→partner) and Y-score (partner→ARAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.308	-1.678	.033	.021	3	3
COAD	EGFR_pY1068 →	-0.484	-2.987	.004	.035	3	2
COAD	INPP4B →	-0.390	-2.991	.044	.036	3	2
COAD	PTEN →	+0.171	+3.008	.018	.019	3	2
UCEC	ERK2 →	+0.133	+1.502	.030	.027	3	2
UCEC	MEK1 →	+0.247	+1.289	.034	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by ARAF expression — UCEC

Explore this box plot interactively →