ARAF

Across TCGA cell cohorts, ARAF protein abundance is significantly associated with the go_rna of many other GO terms, with 630 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ARAF-associated GO terms across cancer lineages are Mitochondrial tRNA modification, Negative regulation of hippocampal neuron apoptotic process, and Valine metabolic process. Each is linked with ARAF in more than 4 cancer types. Because this analysis shows association rather than direction, both ARAF-to-partner and partner-to-ARAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial tRNA modification grouped by ARAF-low versus ARAF-high in BONE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ARAF→partner) and Y-score (partner→ARAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitochondrial tRNA modification →	-0.129	-2.404	.008	.006	3	5
LIVER	Negative regulation of hippocampal neuron apoptotic process →	+1.893	+2.645	.001	.005	3	5
BREAST	Valine metabolic process →	-0.207	-2.194	<.001	.006	3	4
BREAST	L-valine catabolic process →	-0.207	-2.194	<.001	.006	3	4
BLOOD_Leukemia	Positive regulation of endosome organization →	-0.273	-2.187	.001	.001	3	4
BREAST	Branched-chain amino acid metabolic process →	-0.092	-1.557	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 630 associations by consensus.

Mitochondrial tRNA modification by ARAF expression — BONE

Explore this box plot interactively →